Salmonella exploit circadian response

Response to Salmonella infection is controlled by circadian regulation, a finding that “may suggest potential therapeutic strategies for chronopharmacologic interventions,” according to one of two papers on the unwelcome gut crasher published May 27 in the Proceedings of the National Academy of Science. The paper’s full text will be posted at this link.

Inflammatory response in mice to Salmonella typhimurium infection varies with the circadian clock cycle, said the study, Impact of protein on Parkinson’s Disease,led by UC Irvine researchers. The early rest period is the most vulnerable time.

Moreover, a functioning biological clock appears necessary for maximum infection said the study, based on comparisons of normal mice with other that had their circadian cycle disrupted. But once Salmonella is established, the bacterium disrupts the circadian clock to get a better grip. This points out how closely immune response and circadian cycles are connected, the paper said.

“Our hypothesis is that immune factors contribute to the daily coordination of the circadian system, but powerful immunological challenges send signals to disrupt this regulation, possibly by uncoupling some of the circadian outputs, leading to reduction of the amplitude of the oscillations,” the study stated.

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